xzema
Research map, not medical advice. Talk to your doctor, especially for infants.
All treatments
STRONG EVIDENCE

Allergy Immunotherapy

Also discussed as: allergy shots, immunotherapy, allergy immunotherapy, allergen immunotherapy, sublingual immunotherapy, allergy drops

Allergy immunotherapy, including oral immunotherapy (OIT), is recognized as a safe and effective treatment option for certain food allergies, particularly peanut allergy. However, there are potential mild to moderate adverse reactions associated with its use.
Evidence grade · papers only

STRONG EVIDENCE

16 level-I · 18 level-II · 3 level-IV · 1 level-III · 1 level-VII

Research base (design-resolved): 16 systematic review/meta-analysis, 18 randomized trials, 4 observational/descriptive.

Community interest · posts only

high · 7,334 mentions

Most discussed for: other, oral_medication, biologic

What the research says

OIT for peanut allergy is safe and effective, improving quality of life.

Brasal-Prieto et al. (2023), Nutrients. doi:10.3390/nu15173744 · verified

OIT is a safe and efficacious treatment option for children with IgE-mediated, challenge-proven peanut allergy.

Jiao et al. (2022), Frontiers in Immunology. doi:10.3389/fimmu.2022.817062 · verified

OIT induces desensitization in most patients allergic to peanut, milk, and egg.

Mori et al. (2021), Frontiers in Immunology. doi:10.3389/fimmu.2021.636612 · verified

OIT is a promising approach for the management of cow's milk allergy.

Giannetti et al. (2021), Nutrients. doi:10.3390/nu13051525 · verified

67% of the actively treated group tolerated 600 mg of peanut protein.

Schoos et al. (2020), Frontiers in Immunology. doi:10.3389/fimmu.2020.568598 · verified

OIT has shown to be a successful treatment for food allergies, including egg allergies.

Dona et al. (2020), International Journal of Molecular Sciences. doi:10.3390/ijms21145010 · verified

OIT is effective for inducing desensitization in patients with IgE-mediated CMPA.

Saçkesen et al. (2019), Frontiers in Pediatrics. doi:10.3389/fped.2019.00372 · verified

What the community reports

Experience reports, not evidence. Volumes from 1.1M triaged posts.

  • other
  • oral_medication
  • biologic
  • traditional_medicine
  • environmental_change
  • topical_otc

Safety and side effects

There are mild to moderate adverse reactions associated with allergy immunotherapy, and serious adverse events have been reported in a small percentage of cases.

For infants and children

Allergy immunotherapy is approved for children, including those aged 1 to 3 years.

Studied protocols

As reported in the papers, not recommendations.

dose: up to 225 mg of lyophilized hake extract; route: oral

Mayorga et al. (2021), Foods

route: sublingual; duration: 1 year

Mayorga et al. (2021), Foods

route: oral

Brasal-Prieto et al. (2023), Nutrients

route: transdermal; duration: 130 weeks

Brasal-Prieto et al. (2023), Nutrients

route: sublingual; duration: 3 to 5 years

Brasal-Prieto et al. (2023), Nutrients

dose: 600 mg of peanut protein; route: oral

Schoos et al. (2020), Frontiers in Immunology

Drawn from 26 papers · generated 2026-06-11T12:40:48.959818+00:00 · phrasing by gpt-4o-mini, every number computed from the database and every citation machine-verified.