xzema
Research map, not medical advice. Talk to your doctor, especially for infants.
All treatments
STRONG EVIDENCE

Cyclosporine

Also discussed as: cyclosporine, Cyclosporine, cyclosporin, ciclosporin, ciclosporine

Cyclosporine is commonly used for treating atopic dermatitis, particularly in severe cases. It has shown efficacy in clinical studies, but safety concerns exist, particularly regarding kidney function. Parents should consider these factors when researching treatment options.
Evidence grade · papers only

STRONG EVIDENCE

12 level-I · 17 level-II · 3 level-IV · 3 level-VI · 2 level-III · 3 level-VII

Research base (design-resolved): 12 systematic review/meta-analysis, 17 randomized trials, 8 observational/descriptive.

Community interest · posts only

moderate · 2,017 mentions

Most discussed for: oral_medication, topical_prescription, other

What the research says

Cyclosporine A treatment resulted in a SCORAD change of -25.01% at week 12.

Zheng et al. (2024), Frontiers in Immunology. doi:10.3389/fimmu.2024.1367099 · verified

Cyclosporine is commonly used for atopic dermatitis despite not being approved for this indication in many Latin American countries. (n=2)

Soares et al. (2023), Journal of Clinical Medicine. doi:10.3390/jcm12103419 · verified

Efficacy and safety of cyclosporine A were evaluated.

Öğülür et al. (2021), Allergy. doi:10.1111/all.15089 · verified

Oral cyclosporin is an option for severe refractory cases of atopic dermatitis.

Tamagawa‐Mineoka et al. (2020), International Journal of Molecular Sciences. doi:10.3390/ijms21082671 · verified

Cyclosporin has been approved for use in patients with severe adult AD who do not respond to conventional treatments.

Katoh et al. (2020), Allergology International. doi:10.1016/j.alit.2020.02.006 · verified

Cyc-A treatment may be considered in chronic, severe cases of AD in adults.

Wollenberg et al. (2018), Journal of the European Academy of Dermatology and Venereology. doi:10.1111/jdv.14891 · verified

Cyc-A treatment may be considered in chronic, severe cases of AD in adults.

Wollenberg et al. (2018), Journal of the European Academy of Dermatology and Venereology. doi:10.1111/jdv.14888 · verified

What the community reports

Experience reports, not evidence. Volumes from 1.1M triaged posts.

  • oral_medication
  • topical_prescription
  • other
  • biologic

Safety and side effects

Cyclosporine may be associated with nephrotoxicity and renal dysfunction, among other potential side effects.

For infants and children

Cyclosporine is approved for children aged 6 years and older, but its use in younger children and adolescents is considered off-label.

Studied protocols

As reported in the papers, not recommendations.

dose: 100 mg/day; route: oral

Ryoji Tanei (2015), Journal of Clinical Medicine

route: oral; duration: 28 days

Wallimann et al. (2023), Frontiers in Immunology

dose: 2.5 mg/kg; frequency: once daily; route: oral; duration: 12 weeks

Zheng et al. (2024), Frontiers in Immunology

dose: 2.5 mg/kg; frequency: daily; route: oral; duration: 7 days

Woo et al. (2021), Nutrients

dose: 5mg/kg/day; frequency: divided in 2 administrations; route: oral; duration: up to 2 years

Wollenberg et al. (2018), Journal of the European Academy of Dermatology and Venereology

dose: 5 mg/kg/day, gradually decreased to about 2 mg/kg/day; route: oral

Thomas Bieber (2010), Annals of Dermatology

Drawn from 40 papers · generated 2026-06-11T12:40:35.376261+00:00 · phrasing by gpt-4o-mini, every number computed from the database and every citation machine-verified.