Oral/Systemic Corticosteroids
Also discussed as: prednisone, Prednisone, prednisolone, Prednisolone, oral steroids, oral steroid
POPULAR BUT UNPROVEN
4 level-I · 6 level-II · 10 level-IV · 1 level-VI · 3 level-III · 9 level-VII
Heavily discussed in the community (8,762 mentions) but the research base is thin (4 systematic review/meta-analysis, 6 randomized trials, 14 observational/descriptive).
high · 8,762 mentions
Most discussed for: oral_medication, other, biologic
What the research says
Oral corticosteroids are associated with significant side effects and are not meant for chronic use. (n=2)
Soares et al. (2023), Journal of Clinical Medicine. doi:10.3390/jcm12103419 · verifiedPrednisolone treatment attenuated the development of AD condition in mice. (n=24)
Xie et al. (2022), Frontiers in Pharmacology. doi:10.3389/fphar.2022.944801 · verifiedDexamethasone co-activation with PPARg-ligand rosiglitazone is more effective in suppressing AD skin inflammation.
Merk et al. (2021), Frontiers in Immunology. doi:10.3389/fimmu.2021.672808 · verifiedCombined use of dexamethasone and GA enhances suppression of inflammatory markers.
Liu et al. (2013), Molecules. doi:10.3390/molecules18032483 · verifiedDexamethasone significantly reduced skin symptoms in atopic dermatitis models. (n=30)
Lee et al. (2022), Frontiers in Pharmacology. doi:10.3389/fphar.2022.896450 · verifiedMNs greatly facilitated transdermal delivery of CRISPR-Cas9-based genome-editing agents and dexamethasone.
Qu et al. (2022), Theranostics. doi:10.7150/thno.69999 · verifiedDexamethasone inhibits mast cell activation through downregulating Gαi and MRGPRX2 downstream signals.
Ogasawara et al. (2021), Cells. doi:10.3390/cells10112906 · verifiedWhat the community reports
Experience reports, not evidence. Volumes from 1.1M triaged posts.
- oral_medication
- other
- biologic
- topical_prescription
- lifestyle_change
- supplement
Safety and side effects
Oral corticosteroids may lead to various side effects, including weight loss and systemic adverse reactions, although specific details are not always provided.
For infants and children
Oral corticosteroids are used in pediatric patients.
Studied protocols
As reported in the papers, not recommendations.
route: oral
Barzaghi et al. (2012), Frontiers in Immunologydose: 50 mg/kg; frequency: once a day; route: topical or oral; duration: 10 days
Xie et al. (2022), Frontiers in Pharmacologydose: 7.7 ± 4.1 mg/day; frequency: daily or occasional use; route: oral
Ryoji Tanei (2015), Journal of Clinical Medicinedose: 1 mg/kg; frequency: once a day; route: oral; duration: 11 days
Lee et al. (2020), Frontiers in Pharmacologydose: 0.1%; frequency: daily; route: topical; duration: 4 weeks
Yang et al. (2018), Frontiers in Immunologydose: 1.125 mg/kg; route: topical
Li et al. (2022), MoleculesDrawn from 33 papers · generated 2026-06-11T12:41:18.731642+00:00 · phrasing by gpt-4o-mini, every number computed from the database and every citation machine-verified.