Probiotics
Also discussed as: probiotics, probiotic, Probiotics, probiotic supplementation, probiotic foods, probiotic spray
STRONG EVIDENCE
73 level-I · 156 level-II · 13 level-IV · 1 level-VI · 2 level-III · 19 level-VII
Research base (design-resolved): 73 systematic review/meta-analysis, 156 randomized trials, 16 observational/descriptive.
high · 7,393 mentions
Most discussed for: probiotic, dietary_addition, supplement
What the research says
Intervention with pre-, pro-, and synbiotics significantly reduced the incidence of atopic dermatitis. (n=127150)
Wang et al. (2025), Frontiers in Pediatrics. doi:10.3389/fped.2025.1498965 · verifiedProbiotics have shown positive results in treating various diseases, including those affecting the immune system.
Zhou et al. (2024), Frontiers in Nutrition. doi:10.3389/fnut.2024.1355542 · verifiedProbiotics were associated with significant improvements in disease management. (n=15)
Díez‐Madueño et al. (2024), Journal of Clinical Medicine. doi:10.3390/jcm14010019 · verifiedProbiotics may help in restoring gut microbiota balance and reducing atopic dermatitis incidence. (n=4)
Sadowsky et al. (2023), Journal of Clinical Medicine. doi:10.3390/jcm12175534 · verifiedEHCF+LGG was associated with a lower incidence of allergic manifestations and a greater rate of immune tolerance acquisition. (n=365)
Suratannon et al. (2023), Frontiers in Nutrition. doi:10.3389/fnut.2023.1099462 · verifiedPerinatal administration of Lactobacillus rhamnosus strain GG reduced the incidence of atopic eczema in at-risk children during infancy.
Quaranta et al. (2022), Microorganisms. doi:10.3390/microorganisms10122424 · verifiedProbiotics have shown a long-term preventive effect against AD.
Alam et al. (2022), Pathogens. doi:10.3390/pathogens11060642 · verifiedWhat the community reports
Experience reports, not evidence. Volumes from 1.1M triaged posts.
- probiotic
- dietary_addition
- supplement
- topical_otc
- dietary_elimination
- traditional_medicine
Safety and side effects
Some side effects have been reported, including pruritus, eczema, gastrointestinal symptoms, discomfort, redness, and dryness. There have also been reports of changes in stool consistency and rash.
For infants and children
Probiotics have been studied in infants and children, and some formulations are approved for use in this age group.
Studied protocols
As reported in the papers, not recommendations.
dose: 2 × 10^9 CFU/ml; frequency: daily; route: oral; duration: from days 7 to 27 for preventive treatment; from days 45 to 65 for therapeutic treatment
Fu et al. (2017), Frontiers in Immunologydose: 1×10^10 CFU; frequency: daily; route: oral; duration: 8 weeks
Xie et al. (2023), Frontiers in Cellular and Infection Microbiologydose: 20.7 mg/d; frequency: daily; route: oral; duration: 24 weeks
Xie et al. (2023), Frontiers in Cellular and Infection Microbiologydose: 1×10^10 CFU; frequency: twice daily; route: oral; duration: 12 weeks
Xie et al. (2023), Frontiers in Cellular and Infection Microbiologydose: 1×10^9 CFU; frequency: daily; route: oral; duration: 4 weeks
Xie et al. (2023), Frontiers in Cellular and Infection Microbiologydose: 5×10^9 CFU; frequency: daily; route: oral; duration: 8 weeks
Xie et al. (2023), Frontiers in Cellular and Infection MicrobiologyDrawn from 132 papers · generated 2026-06-11T12:39:48.779725+00:00 · phrasing by gpt-4o-mini, every number computed from the database and every citation machine-verified.